Interaction between clopidogrel and proton-pump inhibitors – European Medicines Agency updates warning for clopidogrel-containing medicines

24 March 2010

Following an analysis of new data concerning the possible interactions between clopidogrel and proton-pump inhibitors (PPIs), the European Medicines Agency has recommended an amendment to the existing warning over the concomitant use of clopidogrel-containing medicines and PPIs.

The class warning for all PPIs has been replaced with a warning stating that only the concomitant use of clopidogrel and omeprazole or esomeprazole should be discouraged.

For further information, please see the EMA Public Statement.